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Contraception Journal
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Contraception Highlights March 2013

Editorials

New vision for contraceptive research and development
Regine Sitruk-Ware, Peter Donaldson
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An editorial dedication to bicoastal mentorship
Irwin R. Merkatz, Erika Banks
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Commentaries

Trends in contraceptive use
Jacqueline E. Darroch
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A greenprint for sustainable contraceptive research and development
Kirsten Moore, John Townsend, Jeff Spieler, Patricia S. Coffey, Diana Blithe, Elizabeth Arndorfer, Elizabeth Dawes
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Review articles

Current status of contraceptive vaginal rings
Vivian Brache, Luis José Payán, Aníbal Faundes
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Added health benefits of the levonorgestrel contraceptive intrauterine system and other hormonal contraceptive delivery systems
Ian S. Fraser
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Making of a vaccine preventing pregnancy without impairment of ovulation and derangement of menstrual regularity and bleeding profiles
G.P. Talwar
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7a-Methyl-19-nortestosterone (MENTR): the Population Council's contribution to research on male contraception and treatment of hypogonadism
Eberhard Nieschlag, Narender Kumar, Regine Sitruk-Ware
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New approaches to male non-hormonal contraception
Jean-Jacques Nya-Ngatchou, John K. Amory
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Emergency contraception - mechanisms of action
Kristina Gemzell-Danielsson, Cecilia Berger, Lalitkumar P.G.L.
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Emergency contraception: clinical outcomes 
Anna Glasier
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Vaginal ring delivery of selective progesterone receptor modulators for contraception
Jeffrey T. Jensen
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Contraception technology: past, present and future
Regine Sitruk-Ware, Anita Nath, Daniel R. Mishell
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Clinical Guidelines

Management of postabortion hemorrhage: Release date November 2012 SFP Guideline #20131
Jennifer Kerns, Jody Steinauer
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Original research articles

Impact of the prostaglandin synthase-2 inhibitor celecoxib on ovulation and luteal events in women
Alison B. Edelman, Jeffrey T. Jensen, Carmen Doom, Jon D. Hennebold
Background: Ovarian prostaglandins are critical in normal ovulation processes; thus, their inhibition may provide contraceptive benefits. This study was performed to determine the effect of the cyclooxygenase-2 (COX2) inhibitor celecoxib on ovulation and luteal events in women.
Conclusions: Although treatment with celecoxib before or after the LH surge increases the rate of ovulatory dysfunction, most women ovulate normally. Thus, this selective COX2 inhibitor appears to be of limited usefulness as a potential emergency contraceptive.
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Body composition in lean women with polycystic ovary syndrome: effect of ethinyl estradiol and drospirenone combination            
Kadriye Aydin, Nese Cinar, Duygu Yazgan Aksoy, Gurkan Bozdag, Bulent Okan Yildiz
Background: Limited data are available regarding the potential effects of oral contraceptives (OCs) on body fat distribution particularly in lean women with polycystic ovary syndrome (PCOS). In the current study, we aimed to evaluate the influence of ethinyl estradiol and drospirenone on body composition.
Conclusion: Lean women with PCOS have similar body composition compared to healthy women. OC therapy for 6 months in PCOS patients results in an increased total and trunk fat percentage despite no change in clinical anthropometric measures including weight, BMI and WHR.
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Emergency contraceptive pills as a backup for lactational amenorrhea method (LAM) of contraception: a randomized controlled trial
Omar M. Shaaban, Shaimaa G. Hassen, Sanna A. Nour, Mervat A. Kames, Entsar M. Yones
Background: The use of breastfeeding as a method of birth spacing occasionally ends in ¡°unplanned pregnancy.¡± This is due to unexpected expiration of one or more of the lactation amenorrhea method (LAM) prerequisites. The current study tests a new concept that the in-advance provision of single packet of progestogen emergency contraception (EC) pills during the postpartum LAM counseling may decrease the incidence of unplanned pregnancy during breastfeeding.
Conclusion: In-advance provision of EC pills can increase the rate of initiation of regular contraception once one or more of the prerequisites of LAM expire. Consequently, the use of EC pills as a temporary backup of LAM can decrease the incidence of unplanned pregnancy during breastfeeding. The use of progestogen EC pill during lactation is safe and tolerable.
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Association of body mass index with removal of etonogestrel subdermal implant 
Petra M. Casey, Margaret E. Long, Mary L. Marnach, Jennifer Fleming-Harvey, Linda B. Drozdowicz, Amy L. Weaver
Background: Bleeding irregularities represent the most common etonogestrel subdermal implant (ESI) removal indication.
Conclusions: After adjusting for age and parity, obese women were less likely to have ESI removal for bleeding.
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Strengthening vasectomy services in Rwanda: introduction of thermal cautery with fascial interposition
Michel Labrecque, L¨¦onard Kagabo, Dominick Shattuck, Jennifer Wesson, Christophe Rushanika, Donatien Tshibanbe, Theophile Nsengiyumva, David C. Sokal
Background: Recent developments in vasectomy research indicate that occluding the vas using cautery combined with fascial interposition (FI) significantly lowers failure rates and is an appropriate technology for low-resource settings. We report the introduction of this technique in Ministry of Health (MOH) vasectomy services in Rwanda.
Conclusions: No-scalpel vasectomy with thermal cautery and FI was successfully introduced in vasectomy services in Rwanda, and a similar initiative should be evaluated in other national vasectomy services worldwide.
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Feasibility of LNG-IUS in a baboon model
Jason D. Bell, Ingrid L. Bergin, Melissa F. Natavio, Fatima Jibrel, Melissa K. Zochowski, William J. Weadock, Scott D. Swanson, David M. Aronoff, Dorothy L. Patton
Background: The baboon (Papio hamadryas anubis) is an attractive model for intrauterine contraception research due to anatomic similarity to the human. Although non-human primates have previously been used for intrauterine contraception research, it was unknown whether modern intrauterine devices (IUDs) can be placed in an anatomically similar position in the baboon. This study sought to determine whether human-use IUDs could be seated correctly in the uterus of the baboon.
Conclusions: These findings provide important support for studying IUD safety and efficacy in the baboon.
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The price of emergency contraception in the United States: what is the cost-effectiveness of ulipristal acetate versus single-dose levonorgestrel?
Lisa L. Bayer, Alison B. Edelman, Aaron B. Caughey, Maria I. Rodriguez
Background: Ulipristal acetate (UPA) is a novel form of emergency contraception (EC) that appears to be more effective than the prevailing method, single-dose levonorgestrel (LNG). This study examines the cost-efficacy of UPA compared with LNG.
Conclusions: UPA is cost-effective in preventing unintended pregnancy after unprotected intercourse. Efforts should be promoted to increase access to UPA.
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